WEDNESDAY – September 24, 2025
16:00 – 17:30
REGISTRATION
17:30 – 17:50
OPENING CEREMONY
17:50 – 18:10
THIRTY YEARS OF THE INTERDISCIPLINARY TOXICOLOGY CONFERENCES TOXCON: A BRIEF LOOK BACK
Dubovicky M.
Institute of Experimental Pharmacology and Toxicology, Centre of Experimental Medicine, Slovak Academy of Sciences
19:00
WELCOME RECEPTION
THURSDAY – September 25, 2025
8:00 – 10:00
REGISTRATION/POSTER INSTALLATION
9:00 – 11:00
SESSION 1: MILITARY TOXICOLOGY
Chairpersons: Mojmír Mach and Ondřej Soukup
L1 – NOVICHOK´S AND THE EFFICACY OF CURRENT COUNTERMEASURES
Soukup O., Górecki L., Hepnarová V., Korabecny J., Hrabinova M., Jun D.
Military Faculty of Medicine, University of Defense, Czech Republic
L2 – A NEXT-GENERATION BROAD-SPECTRUM REACTIVATORS AGAINST ORGANOPHOSPHORUS POISONING
Korabecny J., Hrabinova M., Gorecki L., Zdarova-Karasova J.
Military Faculty of Medicine, University of Defense, Czech Republic
L3 – DECONTAMINATION OF CHEMICAL AND BIOLOGICAL AGENTS
Marek J., Zivna N., Ernestova V., Hympanova M., Benkova M., Dlabkova A., Prchal L., Sleha R., Soukup O., Jun D.
Military Faculty of Medicine, University of Defense, Czech Republic
L4 – A-AGENTS: HARD TO FIND? THRILLING DETECTION OF BIOMARKERS IN BIOLOGICAL MATRICES
Prchal L., Dlabková A., Řehulková H.
Biomedical Research Centre, University Hospital in Hradec Králové, Czech Republic
L5 – ENHANCING CONVENTIONAL ANTIDOTAL THERAPY AGAINST NERVE AGENT POISONING WITH THE NOVEL NMDA RECEPTOR ANTAGONIST K2060
Konečný J.
Military Faculty of Medicine, University of Defense, Czech Republic
L6 – BIOTRANSFORMATION OF TACRINE IMPLYING ITS HEPATOTOXICITY AND HOW TO AVOID IT?
Novak M., Soukup O.
University Hospital in Hradec Kralove, Czech Republic
11:00
COFFEE BREAK
11:20 – 12:30
SESSION 2: CARDIOVASCULAR TOXICOLOGY
Chairpersons: Tomáš Perečko and Branislav Kura
L8 – MOLECULAR HYDROGEN AS A PROTECTIVE AGENT AGAINST RADIATION-INDUCED CARDIOTOXICITY
Kura B., Kalocayova B., Sykora M., Pavelkova P., Kornieieva D., Pobijaková M.,
Slezak J.
Institute for Heart Research, Centre of Experimental Medicine, Slovak Academy of Sciences
L9 – FROM ANTIOXIDANT HYPE TO MITOCHONDRIAL REALITY: QUERCETIN IN DIABETIC MYOCARDIAL BIOENERGETICS
Duľová U., Grman M., Kura B., Barteková M.
Institute for Heart Research, Centre of Experimental Medicine, Slovak Academy of Sciences
L10 – THE ROLE OF SULFORAPHANE AND QUERCETIN IN MODULATION OF CELLULAR RESPONSES INDUCED BY DOXORUBICIN IN H9C2 CELLS
Líšková V., Svetláková B., Barančík M.
Institute for Heart Research, Centre of Experimental Medicine, Slovak Academy of Sciences.
L11 – THERAPEUTIC EFFECT OF MOLECULAR HYDROGEN IN HEART FAILURE
Kornieieva D., Sykora M., Kalocayova B., Martiskova A., Szeiffova Bacova B., Kura B.
Institute for Heart Research, Centre of Experimental Medicine, Slovak Academy of Sciences.
L12 – THE ROLE OF CURCUMIN IN MODULATING OF REDOX SIGNALING IN VARIOUS PATHOLOGICAL CONDITIONS IN H9C2 CELLS
Svetláková B., Líšková V., Barančík M.
Institute for Heart Research, Centre of Experimental Medicine, Slovak Academy of Sciences.
12:30 – 13:30
LUNCH
13:30 – 14:30
POSTER
13:30 – 14:30
GENERAL ASSEMBLY OF SETOX
14:30 – 16:50
SESSION 3: IN VITRO TOXICOLOGY
Chairpersons: Helena Kanďárová and Viera Schwarzbacherová
L13 – NOVEL BENZOAZEPINONE DERIVATIVES AS SARS-COV-2 MAIN PROTEASE INHIBITORS: INTEGRATED COMPUTATIONAL AND 3D HUMAN TISSUE SAFETY PROFILING
Pôbiš P., Gabrišová K., Kováčiková L., Májeková M., Berkeš D., Caletková O., Palenčárová A., Kanďárová H.
Institute of Experimental Pharmacology and Toxicology, Centre of Experimental Medicine, Slovak Academy of Sciences
L14 – OCULAR PHOTOIRRITATION TESTING: DEVELOPMENT OF AN INTEGRATED IN SILICO AND IN VITRO STRATEGY
Palenčárová A.M, Pôbiš P., Gabrišová K, Šoltésová Prnová M., Boďo P., Račková L., Kandarova H.
Institute of Experimental Pharmacology and Toxicology, Centre of Experimental Medicine, Slovak Academy of Sciences
L15 – OPTIMIZATION OF THE PROTOCOL FOR O-GLYCANS PROFILING BASED ON MALDI-TOF MS IN CULTURED SKIN CELLS
Račková L., Pakanová Z., Kanďárová H., Baráth P.
1Institute of Chemistry, Slovak Academy of Sciences, Dúbravská cesta 9, Bratislava, Slovakia
2Centre of Experimental Medicine, Slovak Academy of Sciences, Institute of Experimental Pharmacology and Toxicology, Dúbravská cesta 9, Bratislava, Slovakia
L16 – NOVEL SYNTHETIC SERCA ACTIVATORS: A POTENTIAL STRATEGY TO
PREVENT METHYLGLYOXAL-INDUCED IMPAIRMENT
Viskupičová J., Cruz-Cortés C., Micháliková S., Rezbáriková P., Espinoza-Fonseca M.
Institute of Experimental Pharmacology and Toxicology, Centre of Experimental Medicine, Slovak Academy of Sciences
L17 – ANALYSIS OF THE EFFECT OF THE NEONICOTINOID ACETAMIPRID AND THE PHYTOALEXINS CAMALEXIN AND BRASSININ ON WILD-TYPE AND TRDMT1 KNOCKOUT OSTEOSARCOMA CELLS
Schwarzbacherová V., Adamczyk-Grochala J., Wnuk, M.
Department of Biology and Physiology, University of Veterinary Medicine and Pharmacy in Košice
L18 – FROM SIGNALS TO SUSPECTS: EXPLORING CELLULAR DIALOGUE VIA GAP JUNCTIONS IN THE DETECTION OF NON-GENOTOXIC CARCINOGENS
Rico-Guerrero L. A., Bernal K., Kubínová I., Dostálová K., Skupinová A., Sychrová E., Labohá P., Sovadinová I., Babica, P.
Masaryk University, Faculty of Science, RECETOX
L19 – FROM LEGACY TO ALTERNATIVES: PFAS-INDUCED DISRUPTION OF GAP JUNCTIONS AND CANCER-RELATED CELLULAR EVENTS
Bernal K., Skupinová A., Sychrová E., Dostálová K., Sovadinová I., Babica P.
Masaryk University, Faculty of Science, RECETOX
16:50
COFFEE BREAK
17:10 – 17:50
INVITED KEYNOTE LECTURE
Chairperson: Helena Kanďárová
L20 – RISK ASSESSMENT OF MYCOTOXINS
Marko D.
Department of Food Chemistry and Toxicology, University of Vienna, Austria
19:00
GALA-DINNER
FRIDAY – September 26, 2025
9:00 – 10:20
SESSION 5: DEVELOPMENTAL TOXICOLOGY AND ECOTOXICOLOGY
Chairpersons: Michal Dubovický and Tomáš Ječmen
L21 – MATERNAL DEPRESSION AND FUNCTIONAL BRAIN DEVELOPMENT OF OFFSPRING
Dubovický M., Bukátová S., Bogi E., Ujházy E., Brucknerová I.
Institute of Experimental Pharmacology and Toxicology, Centre of Experimental Medicine, Slovak Academy of Sciences
L22 – CANNABIDIOL DISRUPTS TRYPTOPHAN METABOLISM IN THE HUMAN TERM PLACENTA
Portillo R, Abad C, Synova T, Kastner P, Heblik D, Kucera R, Karahoda R, Staud F.
Charles University, Faculty of Pharmacy in Hradec Kralove, Dept. of Pharmacology and Toxicology, Hradec Kralove, Czech Republic
L23 – NUTRITIONAL QUALITY OF RIVER DETRITUS AND ITS INFLUENCE ON JUVENILE FRESHWATER PEARL MUSSEL GROWTH
Ječmen T., Tichá K., Bělonožníková K., Macháček V., Hořická Z., Möhwald M., Ryšlavá H.
Department of Biochemistry, Faculty of Science, Charles University
L24 – THE MOST SUITABLE HONEYBEE MATRICES FOR PESTICIDE MONITORING IN THE LANDSCAPE
Sabo R., Alkassab A.T., Staroň M., Sabová L., Majchrák T., Bischoff G., Pistorius, Janke M., Sučik M., Szabó, I.
The University of Veterinary Medicine and Pharmacy in Košice
10:20
COFFEE BREAK
10:40 – 12:00
SESSION 6: VARIA
Chairpersons: Lucia Kováčiková and Tomáš Smutný
L25 – HIGH-DOSE: OF GANODERMA RESINACEUM POSSESSES PRO-INFLAMMATORY AND CATABOLIC EFFECTS IN ADJUVANT ARTHRITIS
Fakhermanesh M., Sipping K. M. Trésor, Poništ S., Ahmad W., Khademnematolahi S., Mach M., Dráfi F., Švik K., Bauerova K.
Institute of Experimental Pharmacology and Toxicology, Centre of Experimental Medicine, Slovak Academy of Sciences
L26 – RIFAMPICIN AND ITS DERIVATIVES: STABILITY, DISPOSITION, AND AFFINITY TOWARDS PREGNANE X RECEPTOR EMPLOYING 2D AND 3D PRIMARY HUMAN HEPATOCYTES
Smutný T., Smutná L., Lochman L., Kamaraj R., Kučera R., Pávek P.
Charles University, Faculty of Pharmacy in Hradec Králové
L27 – RADIOPROTECTIVE ROLE OF NITRO-FATTY ACIDS IN PRESERVING HEMATOPOIETIC INTEGRITY
Pereckova J., Chrenko D., Pospisil J., Perecko T.
Institute of Biophysics of the CAS, v. v. i.
L28 – HYPOXIA AND HPV STATUS SHAPE CELLULAR, CYTOKINE, AND TRANSCRIPTOMIC RESPONSES TO GAMMA-IRRADIATION IN HEAD AND NECK CANCER
Pereckova J., Vasicek O., Voznicova S., Zavadil-Kokas F., Hrstka R., Perecko T.
Institute of Biophysics of the CAS, v. v. i.
L29 – DEVELOPMENT OF TRIAZINOINDOLE DERIVATIVES AS ALDOSE REDUCTASE INHIBITORS WITH PREDICTED TOXICOLOGY (ADMET) PROFILE
Kovacikova L., Majekova M., Almassy A., Teplanova T., Addova G., Bohac A.
Institute of Experimental Pharmacology and Toxicology, Centre of Experimental Medicine, Slovak Academy of Sciences
12:00
CLOSING CEREMONY
12:20
COFFEE/REFRESHMENTS
PRESENTED POSTERS
TBA