Programme

WEDNESDAY– June 20, 2018

12:00 – 19:00
REGISTRATION

15:30 – 15:45
Official Opening of TOXCON 2018

15:45 – 17:15
Session 1: Toxicology In Vitro
Chairpersons: Helena Kandarova & Dagmar Jírová

L-01
PLENARY LECTURE

Development and Validation of the EpiDerm In Vitro Skin Irritation Protocol for the Assessment of Medical Devices extracts
Kandarova H., Letasiova S., Bachelor M. and Milasova T.
MatTek In Vitro Life Science Laboratories, Mlynske Nivy 73, Bratislava, Slovakia

L-02
Reconstructed 3D human small intestine model for prediction of gastrointestinal toxicity and drug absorption
Markus J., Kandarova H. and Ayehunie S.
MatTek In Vitro Life Science Laboratories, Mlynske Nivy 73, Bratislava, Slovakia

L-03
Sucesfull Evaluation of two EpiOcular Eye Irritation Test Protocols in the International Project CON4EI – CONsortium for In Vitro Eye Irritation Testing Strategy
Letasiova S. and Kandarova H.
MatTek In Vitro Life Science Laboratories, Mlynske Nivy 73, Bratislava, Slovakia

L-04
Selected bisphenols and phthalates screened for estrogen and androgen disruption by in silico and in vitro methods
Dvořáková M., Kejlová K., Rucki M., Jírová D.
National Institute of Public Health, Šrobárova 48, 100 42 Prague 10, Czech Republic

17:15 – 17:30
COFFEE BREAK

17:30 – 18:15
ROUND TABLE
PROMOTING TOXICOLOGY EDUCATION AND CAREER OPPORTUNITIES ABROAD: Useful information for students and postdocs
Chairpersons: Helena Kandarova & Blase Billack

We invite all conference participants, especially doctoral students and new postdoctoral researchers, as well as other interested researchers and toxicologists participate in the Round Table. The aims of this discussion are to increase awareness about career choices and opportunities in toxicology and to increase interest and motivate graduate students to pursue toxicology opportunities abroad as an enhancement to their graduate education. 

18:15 – 19:15
POSTER SESSION 1 – POSTERS No. 01 – 28

List of Posters

 

19:15
WELCOME DRINK & DINNER

 

THURSDAY– June 21, 2018

09:00 – 10:20
Session 2: Cytotoxicity, Carcinogenicity & Genotoxicity I
Chairpersons: Marie Stiborová & Jan Vondráček

L-05
FORMULATION OF APOFERRITIN NANOCARRIER WITH ENCAPSULATED ELLIPTICINE AND STUDY OF ITS PROPERTIES
Indra R., Wilhelm M., Černá T., Heger Z., Dostálová S., Adam V., Eckschlager T., Stiborová M.
Department of Biochemistry, Faculty of Science, Charles University, Prague 2, Czech Republic

L-06
APOFERRITIN NANOCAGE FOR ELLIPTICINE DELIVERY TO NEUROBLASTOMA CELLS
Černá T., Hraběta J., Indra R.1, Heger Z., Adam V., Eckschlager T., Stiborová M.
Department of Biochemistry, Faculty of Science, Charles University, 128 43 Prague, Czech Republic

L-07
DNA ADDUCTS FORMATION BY PLANT ARISTOLOCHIC ACID IS UNIQUE BIOMARKER OF EXPOSURE AND EXPLAIN THE INITIATION PHASE OF UPPER UROTHELIAL CANCER
Stiborová M., Arlt V.M., Schmeiser H.H.
Department of Biochemistry, Faculty of Science, Charles University, Albertov 2030, 128 40 Prague 2, Czech Republic

L-08
CHANGES IN EXOSOME PRODUCTION AFTER CHEMOTHERAPY TREATMENT
Zdurienčíková M., Gronesová P., Sedlák J.
BMC SAS, Cancer Research Institute, Bratislava, Slovakia

10:20 – 10:40
COFFEE BREAK

10:40 – 12:00
Session 3: Cytotoxicity, Carcinogenicity & Genotoxicity II
Chairpersons: Eva Horváthová & Jan Vondráček

L-09
ALTERED EXPRESSION OF BIOTRANSFORMATION ENZYMES IN HEPATOCELLULAR CARCINOMA
Nekvindova J., Hyrslova Vaculova A., Soucek P., Anzenbacher P., Vondracek J., Kiss I., Slaby O., Kala Z., Palicka V.
University Hospital Hradec Kralove, Institute for Clinical Biochemistry and Diagnostics, Hradec Kralove, Czech Republic

L-10
INSIGHTS ON THE RELATIONSHIP BETWEEN STRUCTURE OF PHENYLETHANOID GLYCOPYRANOSIDES AND THEIR ACTIVITIES USING CELL-FREE ASSAYS AND HUMAN CELLS CULTURED IN VITRO
Horváthová E., Mastihuba V., Karnišová Potocká E., Kis P., Gálová E., Ševčovičová A., Klapáková M., Mastihubová M.
1 Cancer Research Institute BMC, Slovak Academy of Sciences, Bratislava, Slovakia

L-11
METABOLISM OF POLYCYCLIC AROMATIC HYDROCARBONS PLAYS A MAJOR ROLE BOTH IN THEIR GENOTOXICITY AND IN THEIR NON-GENOTOXIC EFFECTS
Vondráček J., Hýžďalová M., Pivnička J., Zapletal O., Neča J., Machala M.
Department of Cytokinetics, Institute of Biophysics of the Czech Academy of Sciences, Brno, Czech Republic

L-12
ANTIGENOTOXIC ACTIVITY OF POLYSCIAS FILICIFOLIA EXTRACTS
Figat R., Wójtowicz A., Sobczak M., Śliwińska A., Pietrosiuk A., Nałęcz-Jawecki G.
Department of Enviromental Health Sciences, Medical University of Warsaw, Poland

12:00 – 13:00
LUNCH

13:00 – 15:00
Session 4: Ecotoxicology & Occupational Toxicology
Chairpersons: Jaroslav Mráz & Emília Košťálová

L-13
CYANOBACTERIA – BASED DIETARY SUPPLEMENTS QUALITY MONITORING
Košťálová E., Nagyová V., Kilbergerová H., Chomová L., Kurejová H.
National Reference Center for Ecotoxicology, The Public Health Authority of Slovak Republic in Bratislava, Slovakia

L-14
PROLONGED EXPOSURE TO NON-LETHAL DOSES OF DDT AND DDE SHOWED DIFFERENT EFFECTS ON INSULIN PRODUCTION AND PROTEIN EXPRESSION IN PANCREATIC BETA CELLS
Pavlikova N., Daniel P., Sramek J., Jelinek M., Halada P., Kovar J.
Department of Cellular and Molecular Biology, Third Faculty of Medicine, Charles University, Prague, Czech Republic

L-15
TOXICITY OF HOSPITAL WASTEWATER ASSESSED BY DIFFERENT BIOASSAYS
Jírová G., Vlková A., Wittlerová M., Dvořáková M., Kašparová L., Chrz J., Kejlová K., Wittlingerová Z., Zimová M.
Faculty of Environmental Sciences, Czech University of Life Sciences Prague, Prague, Czech Republic

L-16
FORMATION AND ELIMINATION OF N,N-DIMETHYLFORMAMIDE ADDUCTS WITH BLOOD PROTEINS IN HUMANS
Mráz J., Hanzlíková I., Dušková Š., Tvrdíková M., Chrástecká H.., Vajtrová R., Linhart I.
Centre of Occupational Health, National Institute of Public Health, Prague, Czech Republic

L-17
NANOPARTICLES – POTENTIAL ECOTOXICOLOGICAL THREAT FOR THE ENVIRONMENT
Brandeburová P., Grenčíková A., Žabka D., Mackuľak T.
Department of Environmental Engineering, Faculty of Chemical and Food Technology, Slovak University of Technology, Bratislava, Slovakia

L-18
MICROPLASTICS AS CONTAMINANTS – SCOPE, FATE, AND ENVIRONMENTAL IMPACTS
Grenčíková A., Brandeburová P., Ryba J., Bondarev D., Mackuľak T.
Department of Environmental Engineering, Faculty of Chemical and Food Technology, Slovak University of Technology, Bratislava, Slovakia

15:00 – 15:20
COFFEE BREAK

15:20 – 17:20
Session 5: Military Toxicology
Chairpersons: Jiří Kassa & Blase Billack

L-19
A COMPARISON OF THE REACTIVATING, THERAPEUTIC AND NEUROPROTECTIVE EFFICACY OF TWO NOVEL BISPYRIDINIUM OXIMES (K305, K307) WITH TRIMEDOXIME AND THE OXIME K203 IN RATS AND MICE POISONED WITH TABUN
Kassa J., Hepnarova V., Musilek K., Misik J., Hatlapatkova J., Zdarova Karasova J.
Faculty of Military Health Sciences, Department of Toxicology and Military Pharmacy, Hradec Kralove, Czech Republic

L-20
THE MONOQUARTERNARY REACTIVATORS FOR THE TREATMENT OF ORGANOPHOSHOROUS INTOXICATION
Korabecny J., Gorecki L., Malinak D., Hepnarova V., Hrabinova M., Soukup O., Jun D., Musilek K., Kuca K.
Department of Toxicology and Military Pharmacy, Faculty of Military Health Sciences, University of Defence, Czech Republic

L-21
OXIME ADMINISTRATION AT 100% MTD OR 5% LD50 DOSES- THEIR THERAPEUTIC EFFICACY IN SARIN INTOXICATION TREATMENT
Hepnarova V., Misik J., Hrabinova M., Jun D., Soukup O.
Department of Toxicology and Military Pharmacy, University of Defence, Hradec Kralove, Czech Republic

L-22
DEVELOPMENT OF NOVEL DISINFECTANTS AGAINST PATHOGENS BASED ON QUATERNARY AMMONIUM SALTS
Soukup O., Benkova M.,Marek J., Sleha R., Ryskova L., Malinak D., Jun D.
University Hospital, Hradec Kralove, Sokolska 581,50001 Hradec Kralove, Czech Republic

L-23
DECONTAMINATION OF WARFARE AGENTS
Marek J., Misik J., Matula M., Soukup O.,Jun D.
Biomedical Research Center, Faculty Hospital, Hradec Kralove 500 05, Czech Republic

L-24
HYDROCORTISONE REDUCES VESICATION BY MECHLORETHAMINE IN VIVO
Tumu H., Cuffari B., Billack B.
St. John’s University, Department of Pharmaceutical Sciences, Queens, NY, USA

17:20 – 18:20
POSTER SESSION 2 – POSTERS No. 29 – 66

List of Posters

 

18:20 – 19:00
Annual Meeting of the Slovak Toxicology Society SETOX

19:30
SOCIAL EVENING

 

FRIDAY – June 22, 2018

9:00 – 10:00
Session 6: PHARMACOTOXICOLOGY
Chairpersons: Iveta Bernátová & Mojmír Mach

L-25
SEARCHING FOR NEW OPPORTUNITIES IN THE TREATMENT OF DEPRESSION AND ANXIETY: PRECLINICAL EVALUATION OF COMPOUNDS WITH PYRIDOINDOLE STRUCTURE
Koprdová R., Májeková M., Kiss A., Osacká J., Dremencov E., Csatlósová K., Kokras N., Dalla C., Švecová B., Mach M.
Institute of Experimental Pharmacology and Toxicology, Centre of Experimental Medicine of the Slovak Academy of Sciences, Bratislava, Slovakia

L-26
MODULATING THE EFFECT OF PRENYLATED PHENOLIC COMPOUNDS ON PANCREATIC INS-1E CELLS
Heger V., Viskupicova J., Zoofishan Z., Hunyadi A. Horakova L.
Institute of Experimental Pharmacology and Toxicology, Centre of Experimental Medicine of the Slovak Academy of Sciences, Bratislava, Slovakia

L-27
IMPACT OF PRE-GESTATIONAL STRESS ON OFFSPRING NEUROBEHAVIORAL DEVELOPMENT AND HIPPOCAMPAL FUNCTIONING
Bogi E., Belovicova K., Csatlosova K., Moravcíkova L., Lacinova L., Mach M., Dubovicky M.
Institute of Experimental Pharmacology and Toxicology, Centre of Experimental Medicine of the Slovak Academy of Sciences, Bratislava, Slovakia

L-28
ANALYSIS OF ECG RECORDED FROM RATS PRENATALLY EXPOSED TO STRESS AND VENLAFAXINE
Sasváriová M., Kaprinay B., Salvaras L., Belovičová K., Bögi E.,Knézl V., Barteková M., Stankovičová T., Dubovický M.
Department of Pharmacology and Toxicology, Faculty of Pharmacy, Comenius University in Bratislava, Slovakia

10:00 – 10:15
COFFEE BREAK

10:15 – 11:35
Session 7: RISK ASSESSMENT OF MIXTURES
Chairperson: A. Wallace Hayes

L-29
PROPOSED IN SILICO APPROACHES FOR MIXTURES
Hayes A.W.
Michigan State University, MI USA and University of South Florida, Tampa, FL, USA

L-30
ZEBRAFISH AS A MODEL FOR IDENTIFICATION OF TOXIC MECHANISMS WITH SINGLE CHEMICALS AND MIXTURES
vom Berg C.
Eawag, Überlandstrasse 133, CH-8600 Dübendorf, Switzerland

L-31
ADVANCED IN VITRO APPROACHES FOR COMPARATIVE ASSESSMENT OF HEATED TOBACCO PRODUCTS
Iskandar A., Hoeng J., Peitsch MC.
PMI R&D, Philip Morris Products S.A., Quai Jeanrenaud 5, 2000 Neuchâtel, Switzerland

L-32
EXTRAPOLATING NEW APPROACHES INTO A TIERED APPROACH FOR MIXTURE RISK ASSESSMENT
Dourson M.
Toxicology for Excellence in Risk Assessment, Cincinnati, OH, USA

 

11:35 – 11:45
CLOSING OF THE CONFERENCE