Programme

June 26, 2019  WEDNESDAY

 

15:30 WELCOME, OPENING OF THE CONGRESS 

 

16:00 KEYNOTE 1

Integrating New Emerging Science into the Risk Assessment Paradigm
Prof. W. Hayes

 

16:30 – 18:00 SESSION 1 – THE NEW TOXICOLOGY: MIXTURES 

Assessment of Tobacco Heating System 2.4 on Osteogenic Differentiation of Mesenchymal Stem Cells and Primary Human Osteoblast Compared with Conventional Cigarette
Aspera-Werz R., et al.
Siegfried Weller Institute for Trauma Research, BG Trauma Center, Eberhard Karls University Tübingen, Tübingen, Germany

Transport and Delivery of Evolving Aerosols Generated from Multispecies Mixtures
Arkadiusz K. Kuczaj
University of Twente, Faculty EEMCS, AE Enschede, The Netherlands

Advance In Vitro Models and Approaches for Toxicity Testing of Electronic Cigarette Aerosol Exposure
Diego Marescotti
PMI R&D, Philip Morris Products S.A., Neuchatel, Switzerland

In Vitro Testing Strategies for Investigating Key Cellular Events Involved in Chemically Induced Nonalcoholic Fatty Liver Disease
Fabrice A. Müller, et al.
Departement of Health Sciences and Technology, ETH Zürich

 

19:00 Welcome Cocktail

 

June 27, 2019 THURSDAY

 

9:00 KEYNOTE 2

Real life risk simulations and challenges in precision medicine
Aristides Tsatsakis
University of Crete, Medical School, Heraklion, Crete, Greece

 

9:45 – 11:00 SESSION 2 – NANOTOXICOLOGY & PHARMACOTOXICOLOGY

In vivo toxicological evaluation of silver nanoparticles
Anca Oana Docea, et al.
Department of Toxicology, Faculty of Pharmacy,University of Medicine and Pharmacy of Craiova, Craiova, Romania

Ultrasmall iron oxide nanoparticles induce oxidative stress and alter  vascular responses and iron metabolism in Wistar-Kyoto rats 
Iveta Bernatova, et al.
CEM, Institute of Normal and Pathological Physiology, Bratislava, Slovakia

Aldose Reductase Inhibitors in the Prevention of Diabetic Neurodegenerative Diseases
Cimen Karasu, et al.
Gazi University, Faculty of Medicine, Ankara, Turkey

Effects of Cemtirestat on GSH/GSSG, caspase-3 and protein carbonyl of liver and lung in a rat model of diabetes induced by high fructose diet and streptozotocin: a comperative study with stobadine and epalrestat
Asli Ceylan, et al.
Ankara Yildirim Beyazit University, Ankara, Turkey

11:00 Coffee break

 

11:20 – 12:05 SESSION 3 – NANOTOXICOLOGY & PHARMACOTOXICOLOGY

The effect of venlafaxine on blood pressure and ECG in rats fed with high-fat-fructose diet
Michaela Sasváriová, et al.
Faculty of Pharmacy, Comenius University in Bratislava, Slovakia

In vivo evaluation of composite membranes for treatment of skin wounds
Katarina Valachova, et al.
CEM, Institute of Experimental Pharmacology and Toxicology, Bratislava, Slovakia

Indoxyl Acetate as a Substrate for Lipase Activity Determination
Tomas Valek
Faculty of Military Health Sciences, University of Defense, Hradec Kralove, Czech Republic

12:05 – 13:30 Lunch

 

13:30 – 14:45 SESSION 4 – IN VITRO TOXICOLOGY 

Safety testing of adult novelties using methods in vitro
Lada Belastova, et al.
National Institute of Public Health, Prague, Czech Republic

Nuclear retinoid and retinoid X receptors and their cognate ligands: Insight into toxicology
Július Brtko
Institute of Experimental Endocrinology, BMC, Slovak Academy of Sciences, Bratislava, Slovakia

Use of in vitro reconstructed normal human epidermal model EpiDerm and interleukin-18 (IL-18) to determine the skin sensitization potency of different chemicals
Silvia Letasiova
MatTek In Vitro Life Science Laboratories, Bratislava, Slovakia

Modeling of drug toxicity and absorption using the reconstructed human small intestine epithelium
Jan Markus
MatTek In Vitro Life Science Laboratories, Bratislava, Slovakia

Chronic Hepatoxicity of Cyanobacterial Toxins Assessed In Stem Cell-Based 2d And 3d Hepatic In Vitro Models
Iva Sovadinová
Masaryk University, Faculty of Science, RECETOX, Brno, Czech Republic

14:45 – 15:00 Coffee break

 

15:00 – 17:00 SESSION 5 – IMPLEMENTATION OF 3R IN SLOVAKIA 

Session organized by Slovak National Focal Point for Scientific and Technical matters with European Food Safety Authority (EFSA) and Slovak National Contact Point for the PARERE Network

National Committee for the Protection of Animals Used for Scientific Purposes
Veronika Cubínková
Institute of Neuroimmunology, Slovak Academy of Sciences, Bratislava, Slovakia

3Rs Center at the National Institute of Public Health in the Czech Republic
Dagmar Jirova
National Institute of Public Health, Prague, Czech Republic

Implementation of alternative methods for medical safety evaluation; EU NETVAL test laboratory experiences
Marta Múčková
Hameln, rds, Modra, Slovakia

Implementation of in vitro methods and 3Rs principles into the standards for evaluating the biocompatibility of medical devices (ISO 10993)
Helena Kandarova
Slovak Toxicology Society SETOX, Bratislava, Slovakia

Bird embryo – alternative animal model
Eva Petrovova
University of Veterinary Medicine and Pharmacy in Kosice, Slovakia

State Veterinary and Food Administration of the Slovak Republic and its position in 3R principles
Daniela Bucsuhazyova
State Veterinary and Food Administration of the Slovak Republic, Bratislava, Slovakia

Application of the Three Rs for the purpose of chemical safety assessment
Irina Sadloňová
Ministry of Economy of the Slovak Republic, Centre for Chemical Substances and Preparations, Bratislava, Slovakia

 

17:00 – 19:00 POSTER VIEWING (click to see posters)

 

17:30 – 18:30 General Assembly of the Slovak Toxicology Society SETOX

 

20:00 GALA-DINNER

 

June 28, 2019 FRIDAY 

 

9:00 KEYNOTE 3

Enzymatic oxidation of tyrosine kinase inhibitor vandetanib: detailed study
Marie Stiborová
Faculty of Science, Charles University, Prague, Czech Republic

 

9:30 – 10:00 SESSION 6 – Ecotoxicology

Ecotoxicity of wastewater from health care facilities
Gabriela Jírová
National Institute of Public Health, Prague, Czech Republic

Pilot study on human exposure to bisphenols and phthalates using urine samples
Marketa Dvorakova
National Institute of Public Health, Prague, Czech Republic

 

10:00 – 11:00  SESSION 7 – CYTOTOXICITY, GENOTOXICITY & MUTAGENICITY

Endocrine disruptor bisphenol A shows genotoxic effect on eukaryotic cells
Ivana Ďurovcová
Department of Genetics, Faculty of Natural Sciences, Comenius University in Bratislava, Slovakia

Genotoxic Effect of Non-Thermal Plasma on Various Biological Systems
Stanislav Kyzek
Department of Genetics, Faculty of Natural Sciences, Comenius University in Bratislava, Slovakia

Short-term stimulation with Calypso® 480SC insecticide formulation promotes oxidative stress, genetic instability and apoptosis in bovine lymphocytes in vitro
Viera Schwarzbacherová
Institute of Genetics, University of Veterinary Medicine and Pharmacy in Košice, Slovakia

Determination of genotoxic and antigenotoxic effect by new microscopic method – live-cell imaging
Jana Špačková
Department of Genetics, Faculty of Natural Sciences, Comenius University in Bratislava, Slovakia

 

11:00-11:30 CLOSING OF THE CONGRESS

 

11:30 Coffee break & Refreshment