SEPTEMBER 15, 2021 WEDNESDAY
15:00 – 17:00 REGISTRATION
17:00 WELCOME, OPENING OF THE CONGRESS
17:20 KEYNOTE
Doerenkamp-Zbinden Foundation Awardee 2021:
Alternatives in the 21st century: what has changed in 20 years
Kanďárová H.
Centre of Experimental Medicine SAS, Bratislava, Slovakia
18:00 – 19:00 SESSION 1 – MILITARY TOXICOLOGY
Chairperson: Jiří Kassa & Mojmír Mach
Influence of experimental end point on the therapeutic efficacy of the antinicotinic compounds MB408, MB442 and MB444 in treating nerve agent poisoned mice – a comparison with oxime-based treatment
Kassa J., Timperley ChM., Bird M., Williams RL., Green Ach., Tattersall JEH.
Faculty of Military Health Sciences, University of Defence
Monoquarternary reactivators for the treatment of organophosphorus poisoning
Soukup O.
University Hospital Hradec Kralove
Simultaneous targeting of cholinesterases and N-methyl-D-aspartate receptors by small molecules with therapeutic/prophylactic potential
Korabecny J., Gorecki J., Konecny J., Svobodova B., Hrabinova M., Prchal L., Novak M., Vales K., Horak M.,
Soukup O.
Biomedical Research Center, University Hospital Hradec Kralove
19:00 WELCOME RECEPTION
SEPTEMBER 16, 2021 THURSDAY
9:30 – 12:00 POSTER INSTALLATION & VIEWING
12:00 – 13:30 LUNCH
14:00 – 16:00 SESSION 2 – IN VITRO TOXICOLOGY
Chairperson: Helena Kanďárová & Jan Markus
In vitro skin irritation protocol for the medical devices extracts using EpiDerm model – development, prevalidation and validation
Letasiova S., Markus J., Breyfogle B., Bachelor MA., Kandarova H.
MatTek In Vitro Life Science Laboratories, Bratislava, Slovakia
Evaluation of serum growth factors in wound healing using a full-thickness in vitro human skin model
Puskar M., Armento A., Stolper G., Klausner M., Letasiova S., Hayden P.J.
MatTek In Vitro Life Science Laboratories, Bratislava, Slovakia
Cell culture in microfluidic system
Bernátová S.
Merck Life Science spol. s r. o., Bratislava, Slovakia
Sensitization potential of medical devices detected by in vitro and in vivo methods
Svobodova, L., Rucki, M., Vlkova, A., Kejlova, K., Jirova, D., Dvorakova, M., Kolarova, H., Kandarova, H.,
Heinonen, T.
National Institute of Public Health, Prague, Czech Republic
Respiratory Toxicity Testing Using An In Vitro Human Airway Model, EpiAirway
Markus J., Jackson GR., Klausner M., Hayden P., Letasiova S., Landry T., Ayehunie S.
MatTek In Vitro Life Science Laboratories, Bratislava, Slovakia
16:00 COFFEE BREAK
16:20 – 17:20 SESSION 3 – VARIA
Chairperson: Silvia Letašiová & Marian Rucki
The classification of a substance sensitization potency into UN GHS sub-categories 1A and 1B using the kinetic Direct Peptide Reactivity Assay (kDPRA)
Rucki M., Svobodová L., Jírová D., Kejlová K.
National Institute of Public Health, Prague, Czech Republic
Microbial metabolite butyrate and its influence on systems related to metabolism of xenobiotics
Jourova L., Anzenbacher P., Hudcovic T., Daujat-Chavanieu M., Gerbal-Chaloin S. and Anzenbacherová E.
Department of Medical Chemistry and Biochemistry, Faculty of Medicine and Dentistry, Palacky University Olomouc, Olomouc, Czech Republic
Adducts of xenobiotics with blood proteins as biomarkers of exposure: formation, methods of analysis, applications
Mráz J., Hanzlíková Š., Dušková Š., Linhart I.
National Institute of Public Health, Prague, Czech Republic
Isocitrate dehydrogenase 2 inhibitor Enasidenib synergizes Daunorubicin cytotoxicity by the targeting of aldo-keto reductase 1C3
Morell A., Laštovičková L., Haddad A., Haddad M., Wsól V.
Faculty of Pharmacy in Hradec Králové, Charles University, Czech Republic
17:20 – 17:40 COFFEE BREAK
17:40 – 19:00 POSTER DISCUSSIONS
17:30 – 18:30 General Assembly of SETOX
20:00 GALA-DINNER
SEPTEMBER 17, 2021 FRIDAY
9:00 – 11:15 SESSION 4 – PHARMACOTOXICOLOGY
Chairperson: Petr Hodek & Michal Dubovický
New psychoactive substances: from cul-de-sacs of pharmaceutic research to the illicit street drugs
Linhart I.
University of Chemistry and Technology, Prague, Czech Republic
Vascular function and nitric oxide production in iron oxide nanoparticle-treated rats exposed to acute stress
Bernátová I., Bališ P., Mičurová A., Kluknavský M., Púzserová A., Škrátek M., Maňka J., Líšková S.
Centre of Experimental Medicine SAS, Bratislava, Slovakia
Effects of environmental pollutants bisphenols in isolated rat aorta
Dias P., Tvrdý V., Nejmanová I., Carazo A., Jirkovský E., Pourová J., Mladěnka P.
Department of Pharmacology and Toxicology, Faculty of Pharmacy in Hradec Králové, Charles University, Czech Republic
10:00 -10:15 COFFEE BREAK
ABCB1-resistant phenotype in acute myeloid leukemia
Suchá S.
Department of Pharmacology and Toxicology, Faculty of Pharmacy in Hradec Králové, Charles University, Czech Republic
Effect of flavonoids on copper-triggered haemolysis
Hrubša M., Moravcová M., Argento R., Mladěnka P
Department of Pharmacology and Toxicology, Faculty of Pharmacy in Hradec Králové, Charles University, Czech Republic
The effect of non-canonical amino acids on model redox proteins and electron transfer process
Tuzhilkin R., Černá V., Hudeček J., Šulc M.
Department of Biochemistry, Faculty of Science, Charles University, Prague, Czech Republic
11:15
CLOSING OF THE CONGRESS
POSTER PRESENTATIONS
ECOTOXICOLOGY |
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| P-1 | ARE PLASTIC MICROPARTICLES ABLE TO AFFECT THE INTESTINE FUNCTION OF RAINBOW TROUT JUVENILES? Hodkovicova N.1, Hollerova A.1,2, Gebauer J.1, Tesarik R.1, Faldyna M.1 1Veterinary Research Institute, Department of Infectious Diseases and Preventive Medicine, Brno, Czech Republic; 2University of Veterinary Sciences Brno, Faculty of Veterinary Hygiene and Ecology, Department of Animal Protection and Welfare & Veterinary Public Health, Brno, Czech Republic
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| P-2 | MICROPLASTICS CONTAINED IN PERSONAL CARE PRODUCTS MAY ADVERSELY AFFECT AQUATIC ORGANISMS Hollerová A.1,2, Hodkovicová N.2, Sehonová P.1, Medková D.1,3, Faldyna M.2, Blahová J.1, Svobodová Z.1 1Department of Animal Protection and Welfare & Veterinary Public Health, Faculty of Veterinary Hygiene and Ecology, Veterinary University, Brno, Czech Republic; 2Department of Infectious Diseases & Preventive Medicine, Veterinary Research Institute, Brno, Czech republic; 3Department of Zoology, Fisheries, Hydrobiology and Apiculture, Faculty of AgriSciences Mendel University in Brno, Brno, Czech Republic
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| P-3 | EFFECTS OF NON-STEROIDAL ANTI-INFLAMMATORY DRUGS SUBMITTED IN DIET OF RAINBOW TROUT (ONCORHYNCHUS MYKISS) Koutková Z.1, Hollerová A.1, 2, Hodkovicová N.2, Svobodová Z.1 1Department of Animal Protection and Welfare & Veterinary Public Health, Faculty of Veterinary Hygiene and Ecology, University of Veterinary Sciences Brno, Brno, Czech Republic; 2Department of Infectious Diseases & Preventive Medicine, Veterinary Research Institute, Brno, Czech Republic
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| P-4 | EFFECTS OF FOUR PERSONAL CARE PRODUCTS – TRICLOSAN, TRICLOCARBAN, METHYLPARABEN AND PROPYLPARABEN ON EMBRYONIC STAGES OF CYPRINUS CARPIO Medkova D.1,2, Sehonova P.1, Hollerova A.1,3, Blahova J.1, Doubkova V.1, Mares J.2, Svobodova Z.1 1Department of Animal Protection and Welfare & Veterinary Public Health, Faculty of Veterinary Hygiene and Ecology, University of Veterinary Sciences Brno, Brno, Czech Republic; 2Department of Zoology, Fisheries, Hydrobiology and Apiculture, Faculty of Agrisciences Mendel University in Brno, Brno, Czech Republic; 3Department of Infectious Diseases & Preventive Medicine, Veterinary Research Institute, Brno, Czech Republic
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| P-5 | Effect of novel flame retardants on viability and function of pancreatic beta-cells – preliminary data Pavlíková N.1, Bajard L.2 1Charles University, Third Faculty of Medicine, Department of Biochemistry, Molecular and Cell Biology, Ruská 87, 10000 Praha, Czech Republic; 2Masaryk University, Faculty of Science, RECETOX, Kamenice 5, 62500 Brno, Czech Republic
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| P-6 | Analysis of polychlorinated biphenyls in relevant bee matrices Sabo R., Kasiotis KM., Sabová L., Zafeiraki E., Majchrák T., Machera K. The University of Veterinary Medicine and Pharmacy In Košice, Komenského 73, Košice, Slovakia |
DEVELOPMENTAL TOXICOLOGY |
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| P-7 | The assessment of clinical and laboratory complications in newborns of diabetic mothers and proposal of a manual for obtaining anamnestic data (about newborn) for a neonatologist Gregáňová L.1, Brucknerová J.1, Ujházy E.3, Mach M.3, Dubovický M.3, Brucknerová I.2 1Faculty of Medicine Comenius University in Bratislava, Slovakia; 2Neonatal Department of Intensive Medicine, Faculty of Medicine Comenius University in Bratislava and National Institute of Children´s Diseases, Bratislava, Slovakia; 3Centre of Experimental Medicine SAS, Institute of Experimental Pharmacology and Toxicology, Bratislava, Slovakia
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| P-8 | Effect of maternal depression and antidepressant mirtazapine treatment on selected behavioral variables and synaptophysin expression in the rat offspring Dubovický M.1, Belovičová K.1, Ujházy E.1, Viñas-Noguera M1,2 1Institute of Experimental Pharmacology and Toxicology, Centre of Experimental Medicine, Slovak Academy of Sciences, Bratislava, Slovakia; 2Faculty of Natural Sciences, Comenius University, Bratislava, Slovakia
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| P-9 | Effect of pro-inflammatory cytokines on ABC and SLC transporters gene expression in human placental cell line and villous explants Dudicova S., Tupova L., Ceckova M. Department of Pharmacology and Toxicology, Faculty of Pharmacy in Hradec Kralove, Charles University, Czech Republic |
CYTOTOXICITY, CARCINOGENICITY & GENOTOXICITY |
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| P-10 | CARDIOTOXIC POTENTIAL OF DAUNORUBICINOL WITH REGARD TO ISOLATED NEONATAL RAT CARDIOMYOCYTES Applová L.1, Kocúrová J.2, Hatoková P.2, Váňová N.2, Kubeš J.1, Skalická V.1, Štěrbová P.2, Šimůnek T.1 1 Department of Biochemical Sciences, Faculty of Pharmacy in Hradec Králové, Czech Republic, 2 Department of Pharmaceutical Chemistry and Drug Analysis, Faculty of Pharmacy in Hradec Králové, Czech Republic
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| P-11 | STRUCTURE DERIVATION OF SALIDROSIDE AND THE ACTIVITY OF DERIVATIVES IN CELLULAR AND CELL-FREE ASSAYS Horváthová E.1, Mastihubová M.2, Gálová E.3, Ševčovičová A.3, Antalová V.3, Mastihuba V.2 1Cancer Research Institute, Biomedical Research Center, Slovak Academy of Sciences, Bratislava, Slovakia; 2Institute of Chemistry, Slovak Academy of Sciences, Bratislava, Slovakia; 3Department of Genetics, Faculty of Natural Sciences, Comenius University, Bratislava, Slovakia
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| P-12 | LONG TERM EFFECTS OF SULFUR MUSTARD RE-TREATMENT ON THE HaCaT CELLS Jost P., Muckova L., Pejchal J. Department of Toxicology and Military Pharmacy, Faculty of Military Health Sciences, University of Defence, Hradec Kralove, Czech Republic
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| P-13 | INVESTIGATION OF XK469 POTENTIAL IN THE MANAGEMENT OF ANTHRACYCLINE CARDIOTOXICITY Skalická V.1, Kubeš J.1, Applová L.1, Jirkovská A.1 1Department of Biochemical Sciences, Faculty of Pharmacy in Hradec Králové, Charles University, Czech Republic |
NANOTOXICOLOGY |
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| P-14 | POLYETHYLENE GLYCOL-ALENDRONATE-COATED MAGNETITE NANOPARTICLES DO NOT PRODUCE NEGATIVE EFFECTS ON CARDIOVASCULAR FUNCTIONS IN SPONTANEOUSLY HYPERTENSIVE RATS Kluknavský M.1, Líšková S.1,3, Bališ P.1, Mičurová A.1, Oleksa V.2, Patsula V.2, Macková H.2, Horák D.2, Bernátová I.1 1Institute of Normal and Pathological Physiology, Centre of Experimental Medicine, Slovak Academy of Sciences, Bratislava, Slovakia,2Institute of Macromolecular Chemistry, Czech Academy of Sciences, Prague, Czech Republic, 3Institute of Pharmacology and Clinical Pharmacology, Faculty of Medicine, Comenius University, Bratislava, Slovakia
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| P-15 | F3O4@PEG NANOPARTICLES REDUCED BLOOD PRESSURE WHILE HIGH BLOOD PRESSURE ACCELERATED NANOPARTICLE ELIMINATION FROM CIRCULATION IN SHR RATS Mičurová A.1, Kluknavský M. 1, Bališ P.1, Okruhlicová Ľ.2, Škrátek M.3, Maňka J.3, Bernátová I.1 1Institute of Normal and Pathological Physiology, 2Institute for Heart Research, Centre of Experimental Medicine, 3Institute of Measurement Science, Slovak Academy of Sciences, Bratislava, Slovakia
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| P-16 | STUDY OF NEUROTOXIC POTENTIAL OF GOLD AND SILVER NANOPARTICLES IN HUMAN NEUROBLASTOMA CELLS SH-SY5Y Scsukova S.1, Martincova M.1,2, Bujnakova Mlynarcikova A.1 1Institute of Experimental Endocrinology, Biomedical Research Center, Slovak Academy of Sciences, Dubravska cesta 9, Bratislava, Slovakia; 2Department of Animal Physiology and Ethology, Faculty of Natural Sciences, Mlynska dolina, Ilkovicova 6, Comenius University in Bratislava, Slovakia |
TOXICOLOGY IN VITRO |
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| P-17 | BISPHENOL ANALOGS AF AND S: EFFECTS ON PRODUCTION OF ANGIOGENESIS-RELATED FACTORS BY COV434 HUMAN GRANULOSA CELL LINE Bujňáková Mlynarčíková A., Scsuková S. Institute of Experimental Endocrinology, Biomedical Research Center, Slovak Academy of Sciences, Bratislava, Slovakia
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| P-18 | SCREENING OF SYNTHETIC HETEROCYCLIC COMPOUNDS AS ANTIPLATELET DRUGS Carazo A.1, Hrubša M.1, Karlíčková J.2, Fadraersada J.1, Macáková K.3, Brahmachari G.4, Mladěnka P.1 1The Department of Pharmacology and Toxicology, Faculty of Pharmacy, Charles University, Hradec Králové, Czech Republic, 2The Department of Pharmaceutical Botany, Faculty of Pharmacy, Charles University, Hradec Králové, Czech Republic, 3The Department of Pharmacognosy, Faculty of Pharmacy, Charles University, Hradec Králové, Czech Republic, 4Department of Chemistry, Visva-Bharati (Central University), Santiniketan, India
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| P-19 | THE EFFECTS OF CURCUMIN ON VIABILITY AND EXPRESSION OF STEROIDOGENIC GENES IN HUMAN ADRENOCORTICAL NCI-H295R CELLS Fialkova V.1, Duranova H.1, Spevakova I.1, Ziarovska J.2, Knazicka Z.3 1AgroBioTech Research Centre, Slovak University of Agriculture, Nitra, Slovakia; 2Faculty of Agrobiology and Food Resources, Slovak University of Agriculture, Nitra, Slovakia; 3Faculty of Biotechnology and Food Sciences, Slovak University of Agriculture, Nitra, Slovakia
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| P-20 | THE IMPACT OF LEPIDIUM MEYENII (MACA) ON MITOCHONDRIAL ACTIVITY AND CELL MEMBRANE INTEGRITY IN TM3 LEYDIG CELLS Jambor T.1, Arvay J.2, Ivanisova E.3, Lukac N.1 1Slovak University of Agriculture in Nitra, Faculty of Biotechnology and Food Sciences, Department of Animal Physiology, Nitra, Slovakia; 2Slovak University of Agriculture in Nitra, Faculty of Biotechnology and Food Sciences, Department of Chemistry, Nitra, Slovakia; 3Slovak University of Agriculture in Nitra, Faculty of Biotechnology and Food Sciences, Department of Technology and Quality of Plant Products, Nitra, Slovakia
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| P-21 | CYTOTOXICITY SCREENING OF CLASSICAL AND NEXT-GENERATION BISPHENOLS IN VITRO Jirkovský E., Carazo A., Dias P., Tvrdý V., Mladěnka P. Department of Pharmacology and Toxicology, Faculty of Pharmacy in Hradec Králové, Charles University, Hradec Králové, Czech Republic
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| P-22 | THE POTENTIAL OF THE 3D RECONSTRUCTED HUMAN TISSUE MODELS TO CORRECTLY PREDICT THE PHOTO-IRRITATION OF MEDICAL DEVICES AND PHARMACEUTICALS Pôbiš P.1,2, Kandarova H.1,2 1Institute of Experimental Pharmacology and Toxicology, Centre of Experimental Medicine of the Slovak Academy of Sciences, Bratislava, Slovakia; 2Faculty of Chemical and Food Technology (FCHPT) at Slovak University of Technology (SUT)
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| P-23 | IMPLEMENTATION OF THE ISO 10993-5 FOR MEDICAL DEVICES BIOCOMPATIBILITY TESTING: EXPERIENCES GAINED WITH THE 3T3 NEUTRAL RED UPTAKE TEST Kubalcová J.1, Pôbiš P.1,2, Kandarova H.1,2 1Faculty of Chemical and Food Technology (FCHPT) at Slovak University of Technology (SUT); 2Institute of Experimental Pharmacology and Toxicology, Centre of Experimental Medicine of the Slovak Academy of Sciences, Bratislava, Slovakia
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| P-24 | II VITRO MODEL FOR EVALUATION OF NEUROTOXICITY AND NEUROPROTECTION Pulkrabkova L.1,2, Muckova L.1,2, Kobrlova T.1, Soukup O.1 1Biomedical Research Center, University Hospital Hradec Kralove, Sokolska 581, 500 05, Hradec Kralove (Czech Republic); 2Department of Toxicology and Military Pharmacy, Faculty of Military Health Sciences, University of Defence, Trebesska 1575, Hradec Kralove (Czech Republic)
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| P-25 | CO-EXPOSURE OF CITRININ WITH PTEROSTILBENE AND THEIR IMPACT ON METABOLIC ACTIVITY OF HT-29 CELLS Spevakova I.1, Capcarova M.2, Fialkova V.1, Ziarovska J.3 1AgroBioTech Research Centre of the Slovak University of Agriculture in Nitra, Nitra, Slovak Republic; 2Department of Animal Physiology, Faculty of Biotechnology and Food Sciences, Slovak University of Agriculture in Nitra, Nitra, Slovak Republic; 3Department of Genetics and Plant Breeding, Faculty of Agrobiology and Food Resources, Slovak University of Agriculture in Nitra, Nitra, Slovak Republic
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PHARMACOTOXICOLOGY |
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| P-26 | BEHAVIORAL CONSEQUENCES OF REPEATED ADMINISTRATION OF THE PYRIDOINDOLE DERIVATIVE SMe1EC2M3 IN AN ANIMAL MODEL OF CHRONIC MILD STRESS Koprdová R.1, Ballóová A.1,2, Ujházy E.1, Mach M.1 1Institute of Experimental Pharmacology and Toxicology, Centre of Experimental Medicine, Slovak Academy of Sciences, Bratislava, Slovakia; 2Department of Pharmacology, Jessenius Faculty of Medicine in Martin, Comenius University in Bratislava, Slovakia
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| P-27 | PRECLINICAL AND CLINICAL ASPECTS OF PHARMACORESISTANT DEPRESSION Ballóová A.1,2, Koprdová R.1, Mach M.1 1 Institute of Experimental Pharmacology and Toxicology, Centre of Experimental Medicine, Slovak Academy of Sciences, Bratislava, Slovakia; 2 Department of Pharmacology, Jessenius Faculty of Medicine in Martin, Comenius University in Bratislava, Slovakia
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| P-28 | ICRF-193 AFFORDS SUPERIOR PROTECTION AGAINST ANTHRACYCLINE CARDIOTOXICITY THAN DEXRAZOXANE Jirkovská A.1, Karabanovich G.1, Kubeš J.1, Skalická V.1, Melnikova I.1, Korábečný J.2, Kučera T.2, Jirkovský E.1, Nováková L.1, Škoda J.1, Štěrba M.3, Austin CA.4, Šimůnek T.1, Roh J.1 1Univerzita Karlova, Farmaceutická fakulta v Hradci Králové; 2Biomedical Research Center, Fakultní nemocnice Hradec Králové; 3Univerzita Karlova, Lékařská fakulta v Hradci Králové; 4Newcastle University, Biosciences Institute
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| P-29 | ANTHRACYCLINE CARDIOTOXICITY IS DIFFERENTLY AFFECTED BY VARIOUS TOPOISOMERASE II INHIBITORS Kubes J.1, Karabanovich G.2, Melnikova I.2, Skalicka V.1, Applova L.1, Jirkovska A.1, Roh J.2, Simunek T.1 1Department of Biochemical Sciences, Faculty of Pharmacy in Hradec Králové, Charles University, Czech Republic; 2Department of Organic and Bioorganic Chemistry, Faculty of Pharmacy in Hradec Králové, Charles University, Czech Republic
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| P-30 | DIFFERENTIAL EXPRESSION OF OCTN1 AND ABCC4 IN AML; IMPLICATIONS FOR PROGNOSIS AND PHARMACOTHERAPY Šorf A.1, Nálevková K.1, Suchá S. 1, Dudičová S. 1, Čečková M.1 1 Department of Pharmacology and Toxicology, Faculty of Pharmacy, Charles University, Czech Republic.
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| P-31 | CRISPR/CAS9-MEDIATED KNOCKOUT OF LRP2 GENE IN CANCER CELL LINES Ďurinová A.1, Smutná L.1, Smutný T.1, Trejtnar F.1, Pávek P.1 1 Department of Pharmacology and Toxicology, Faculty of Pharmacy in Hradec Králové, Charles University, Czech Republic
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| P-32 | 3D PRIMARY HUMAN HEPATOCYTE SPHEROIDS AS A MODEL FOR THE STUDY OF GENE EXPRESSION CHANGES INDUCED BY PREGNANE X RECEPTOR Smutny T.1, Bernhauerova V.2, Smutna L.1, Tebbens JD.2, Pavek P.1 1Department of Pharmacology and Toxicology, Faculty of Pharmacy in Hradec Kralove, Charles University, Hradec Kralove, Czech Republic; 2Department of Biophysics and Physical Chemistry, Faculty of Pharmacy in Hradec Kralove, Charles University, Hradec Kralove, Czech Republic
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| P-33 | ACTIVATION OF PPAR GAMMA AND NRF2 IN THE IMPROVEMENT OF ANTIOXIDANT OUTPUTS IN OXIDATIVE STRESS, NOS, RXR IN HYPERTENSION Dovinova I.1, Barančík M.1, Kvandová M.2, Bališ P.1, Puzserová A.1,Klukňavsky M.1, Macejova D.3, Brtko J.3 1Centre of Experimental Medicine Slovak Acad Sciences, Bratislava, Slovakia, 2Center for Cardiology I, Molecular Cardiology, University Medical Center, Mainz, Germany, 3Biomedicine centrum Slovak Acad Sciences, Bratislava, Slovakia.
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| P-34 | HYPOXIA POTENTIATES PRO-APOPTOTIC EFFECT OF STEARIC ACID AND INHIBITS PROTECTIVE EFFECT OF OLEIC ACID IN HUMAN PANCREATIC Β-CELLS Šrámek J.1, Němcová-Fürstová V.1, Polák J.2, Kovář J.1 1Charles University – Third Faculty of Medicine, Department of Biochemistry, Cell and Molecular Biology & Center for Research of Diabetes, Metabolism and Nutrition, Prague, Czech Republic; 2Charles University – Third Faculty of Medicine, Department of Pathophysiology, Prague, Czech Republic |
MILITARY TOXICOLOGY |
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| P-35 | EVALUATION OF CYTOTOXICITY AND SUSCEPTIBILITY TO FRANCISELLA TULARENSIS OF SELECTED QUATERNARY AMMONIUM COMPOUNDS Hympanova M.1,4, Markova A.2,4, Pulkrabkova L.2,4, Benkova M.4, Krocova Z.3, Marek J.1,2 1Department of Epidemiology, 2Department of Toxicology and Military Pharmacy and 3Department of Molecular Pathology and Biology, Faculty of Military Health Sciences, University of Defence, Trebesska 1575, 500 05 Hradec Kralove, Czech Republic; 4 Biomedical Research Centre, University Hospital Hradec Kralove, Sokolska 581, 500 05 Hradec Kralove, Czech Republic
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| P-36 | DISCOVERY OF FLUOREN-9-AMINES AS SELECTIVE BUTYRYLCHOLINESTERASE INHIBITORS AND N-METHYL-D-ASPARTATE RECEPTOR ANTAGONISTS Konecny J.1,2, Misiachna A.3,4,5, Hrabinova M.1,2, Pulkrabkova L.1,2, Benkova M.2, Prchal L.2, Kucera T.1,2, Kobrlova T.2, Finger V.2,6, Kolcheva M.3,4, Kortus S.3,4, Jun D.1,2, Valko M.7, Horak M.3,4, Soukup O.1,2, Korabecny J.1,2 1Department of Toxicology and Military Pharmacy, Faculty of Military Health Sciences, University of Defence, Trebesska 1575, 500 01, Hradec Kralove, Czech Republic; 2Biomedical Research Center, University Hospital Hradec Kralove, Sokolska 581; 3Institute of Experimental Medicine of the Czech Academy of Sciences, Videnska 1083, 142 20 Prague, Czech Republic; 4Institute of Physiology of the Czech Academy of Sciences, Videnska 1083, 142 20 Prague, Czech Republic; 5Department of Physiology, Faculty of Science, Charles University in Prague, Albertov 6, 128 43 Prague, Czech Republic; 6Department of Organic and Bioorganic Chemistry, Faculty of Pharmacy in Hradec Kralove, Charles University, Akademika Heyrovskeho 1203, 500 05 Hradec Kralove, Czech Republic; 7Faculty of Chemical and Food Technology, Slovak University of Technology, Radlinskeho 9, 812 37 Bratislava, Slovakia
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| P-37 | DEVELOPMENT OF NOVEL DUALLY-ACTING DERIVATIVES 7-PHENOXYTACRINE AS A POTENTIAL PROPHYLACTIC AGAINST NERVE AGENT POISONING Svobodova B.1,2, Korabecny J.1,2, Hrabinova M.1,2, Prchal L.1, Novak M.1, Vales K.3, Horak M.4, Soukup O. 1,2 1Biomedical Research Center, University Hospital Hradec Kralove, Sokolska 581, 500 05, Hradec Kralove, Czech Republic; 2Department of Toxicology and Military Pharmacy, Faculty of Military Health Sciences, University of Defence, Trebesska 1575, 500 01, Hradec Kralove, Czech Republic; 3National Institute of Mental Health, Topolova 748, 250 67, Klecany, Czech Republic; 4Institute of Experimental Medicine of the Czech Academy of Sciences, Videnska 1083, 14220, Prague 4, Czech Republic |