Poster presentations

Ecotoxicology

P-1 ENVIRONMENTAL OCCURRENCE AND TOXICITY OF ORGANIC UV FILTERS

Cahová J.1, Blahová J.1, Svobodová Z.1

1 Department of Animal Protection, Welfare and Behaviour, Faculty of Veterinary Hygiene and Ecology, University of Veterinary and Pharmaceutical Sciences Brno, Brno,  Czech republic

P-2 Aquatic ecosystems comparison from the point of view of heavy metals pollution

Dvořák P.1, Andreji J.2, Dvořáková Líšková Z.3, Roy K.1, Mráz J.1

1 University of South Bohemia in Ceske Budejovice, Faculty of Fisheries and Protection of Waters, South Bohemian Research Center of Aquaculture and Biodiversity of Hydrocenoses, Institute of Aquaculture and Protection of waters, Ceske Budejovice, Czech Republic; 2 Department of Poultry Science and Small Farm Animals, Slovak University of Agriculture, Nitra, Slovak Republic; 3Faculty of Economy, University of South Bohemia, Ceske Budejovice, Czech Republic

P-3 Study of the impact of silver nanoparticles on representatives of soil fauna

Hlavkova D., Havelkova B., Beklova M.

Department of Ecology and Diseases of Game, Fish and Bees, Faculty of Veterinary Hygiene and Ecology, University of Veterinary and Pharmaceutical Sciences Brno, Czech Republic

P-4 THE EFFECTS OF MICROPLASTICS ON RAINBOW TROUT (ONCORHYNCHUS MYKISS) 

Hodkovicova N.1,2, Minarova H.2,3, Caloudova H.1, Faldyna M.2, Marsalek P.1, Svobodova Z.

1University of Veterinary and Pharmaceutical Sciences Brno, Faculty of Veterinary Hygiene and Ecology, Department of Animal Protection, Welfare and Behaviour, Brno, Czech Republic; 2 Veterinary Research Institute, Department of Immunology, Brno, Czech Republic; 3 University of Veterinary and Pharmaceutical Sciences Brno, Faculty of Veterinary Hygiene and Ecology, Department of Ecology and Diseases of Game, Fish and Bees, Brno, Czech Republic

P-5 NOTHOBRANCHIUS FURZERI AND TRIPLOID FORM DANIO RERIO AS A MODEL ORGANISMS FOR ENDOCRINE POLUTANTS TESTING IN WATER TOXICOLOGY

Koutková Z., Svobodová Z.

Unviersity of Veterinary and Pharmaceutical Sciencis Brno, Institute Animal Protection and Welfare, Department Veterinary Toxikology and Toxikology of Foodstuff, Brno, Czech Republic

P-6 2-D Electrophoresis as a Tool for Determination the Markers of Acute Toxicity in Pancreatic Beta Cells Exposed to a Lethal Dose of the Organochlorine Pesticide DDT

Pavlikova N.1, Sramek J.1, Jelinek M.1, Halada P.2, Kovar J.1

1Department of Cellular and Molecular Biology, Third Faculty of Medicine, Charles University, Prague, Czech Republic; 2Laboratory of Molecular Structure Characterization, Institute of Microbiology, Academy of Sciences of the Czech Republic, Prague, Czech Republic

P-7 FORMETANATE ADVERSE EFFECTS ON DEVELOPMENTAL STAGES OF HONEYBEES

Sabo R., Sabová L., Legáth J.

Department of Pharmacology and Toxicology, University of Veterinary Medicine and Pharmacy in Kosice, Komenského 73, 041 81 Košice, Slovakia

P-8 Effect of antidepressant sertraline on rainbow trout

Václavík J., Svobodová Z.

Veterinary and Pharmaceutical University Brno, Palackého třída 1946/1, 61242, Brno, Czech Republic

 

Developmental Toxicology

P-9 Clinical consequences of most frequent trisomies on postnatal neonatal adaptation

Brucknerová I.1, Labašková S. 2, Brucknerová J.2, Dubovický M.3, Ujházy E.3

1Neonatal Department of  Intensive Medicine, Faculty of Medicine, Comenius University in Bratislava, Libova 1, Bratislava, Slovakia; 2Faculty of Medicine, Comenius University in Bratislava, Špitalská 24, Bratislava, Slovakia; 3Institute of Experimental Pharmacology and Toxicology, Slovak Academy of Sciences, Dúbravská cesta 9, Bratislava, Slovakia

P-10 Effects of bupropion administration during pregnancy and lactation on maternal behavior and selected reproductive variables in rats

Csatlosova K.1,2, Simoncicova E.1,2, Bögi E.1, Dubovicky M.1

1Institute of Experimental Pharmacology and Toxicology, Centre of Experimental Medicine of the Slovak Academy of Sciences, Bratislava, Slovak Republic; 2Department of Pharmacology, Jessenius Faculty of Medicine, Comenius University, Martin, Slovak Republic

P-11 The effect of prenatal and early postnatal exposure to phthalate mixture on anxiety-like and depression-like behaviour in rats

Morová M., Štefunková M., Senko T., Olexová L., Kršková L.

Department of Animal Physiology and Ethology, Faculty of Natural Sciences, Comenius University in Bratislava, Slovakia

P-12 Impact of prenatal hypoxia on neurotransmitter systems in the rat brain

Piešová M.1,2, Koprdová R.1, Hadová K.3, Křenek P.3, Mach M.1

1Institute of Experimental Pharmacology and Toxicology, Centre of Experimental Medicine, Slovak Academy of Sciences, Bratislava, Slovakia; 2Jessenius Faculty of Medicine in Martin, Comenius University, Bratislava, Slovakia; 3Faculty of Pharmacy, Comenius University, Bratislava, Slovakia

P-13 COMPARISON OF EMBRYOTOXIC EFFECTS OF VENOMS IN SELECTED AFRICAN AND ASIAN SNAKE SPECIES OF THE GENUS NAJA

Polláková M.1, Andrejčáková Z.1, Petrilla V.1, Ondrašovičová S.1, Vlčková R.1, Petrillová M.2, Sopková D.1

The University of Veterinary Medicine and Pharmacy in Kosice, Department of Physiology, Košice, Slovakia; The University of Veterinary Medicine and Pharmacy in Kosice, Department of General Education Subjects, Košice, Slovakia;

P-14 EFFECT OF PRE-GESTATIONAL STRESS AND VENLAFAXINE TREATMENT ON HIPPOCAMPAL SYNAPTIC STRUCTURE IN RAT OFFSPRING

Simoncicova E.1,2, Belovicova K.1, Csatlosova K.1,2, Dubovicky M.1, Bogi E.1

1Institute of Experimental Pharmacology and Toxicology, Centre of Experimental Medicine of the Slovak Academy of Sciences, Bratislava, Slovak Republic; 2Department of Pharmacology, Jessenius Faculty of Medicine, Comenius University, Martin, Slovak Republic

P-15 Evaluation of the effects of a standardized Cynara cardunculus leaf extract on prenatal Rat development

Ujhazy E.1, Farkas M.1, Koprdova R.1, Nagy M.2, Mucaji P.2, Brucknerova I.3, Mach M.1

1Centre of Experimental Medicine of the Slovak Academy of Sciences, Institute of Experimental Pharmacology and Toxicology, Bratislava, Slovakia; 2Faculty of Pharmacy, Comenius University in Bratislava, Department of Pharmacognosy and Botany, Bratislava, Slovakia; 3Neonatal Department of Intensive Medicine, Faculty of Medicine, Commenius University  and National Institute of Children´s Diseases, Bratislava, Slovakia

 

Veterinary Toxicology

P-16 THE CASE OF PIG POISONING BY THE PESTICIDE PRODUCT REGLONE (DIQUAT)

Široká Z.1, Svoboda M.2, Nágl I.3

1 Department of Animal Protection, Welfare and Behaviour, University of Veterinary and Pharmaceutical Sciences Brno, Czech Republic, 2 Ruminant and Swine Clinic, University of Veterinary and Pharmaceutical Sciences Brno, Czech Republic, 3 State Veterinary Institute Praha, Czech Republic

 

Immunotoxicology

P-17 ENZYMATIC DESIALYLATION OF LUNG EPITHELIUM INCREASES BINDING OF LECTIN PAIIL, PSEUDOMONAS AERUGINOSA VIRULENCE FACTOR

Kubíčková B.1, Rychnová J.1, Dostálová K.1, Vyhnalová K.1, Mrázková J.3, Mandys V.3, Wimmerová M.2, Stiborová M.1, Hodek P.1

1 Department of Biochemistry, Faculty of Science, Charles University, Albertov 2030, Prague, Czech Republic; 2 Department of Biochemistry, Faculty of Science, Masaryk University, Kamenice 753/5, Brno, Czech Republic; 3 Department of Pathology, Third Faculty of Medicine, Charles University, Ruská  87, Prague, Czech Republic

P-18 Feasibility of Direct Peptide Reactivity Assay (DPRA) in evaluation of sensitization potential of chemicals and mixtures

Rucki M.1, Bělastová L.1,2, Vlková A.1, Kejlová K.1, Jírová D.1

1Centre of Toxicology and Health Safety, National Institute of Public Health, Prague, Czech Republic,2Faculty of Medicine and Dentistry, Palacký University, Olomouc, Czech Republic

 

Metabolism of Xenobiotics

P-19 TYROSINE KINASES INHIBITORS VANDETANIB AND LENVATINIB INDUCE THE EXPRESSION OF CYTOCHROME P450 1A1 IN RATS IN VIVO

Dračínská H., Baráčková P., Jelínková S., Stiborová M.

Department of Biochemistry, Faculty of Science, Charles University, Prague, Czech Republic

P-20 IMPACT OF DIHYDROMYRICETIN ON ALCOHOL METABOLISM

Hodek P.1, Skotnicová A.1, Hauptmanová G.1, Kutinová-Canová N.2, Stiborová M.1

1Department of Biochemistry, Faculty of Science, Charles University, Prague, Czech Republic; 2Institute of Pharmacology, 1st Faculty of Medicine, Charles University, Prague, Czech Republic

P-21 Metabolism of tyrosine kinase inhibitor Cabozantinib by liver microsomes

Indra R.1, Jurecka T.1, Vavrova K.1, Pompach P.1, Heger Z.2, Adam V.2, Stiborova M.1

1Department of Biochemistry, Faculty of Science, Charles University, Prague, Czech Republic 2Department of Chemistry and Biochemistry, Laboratory of Metallomics and Nanotechnology, Mendel University in Brno, Brno, Czech Republic

P-22 Interactions of tyrosine kinase inhibitors vandetanib, lenvatinib, and cabozantinib with ellipticine influence the ellipticine-DNA aduct formation in vitro and in vivo

Stiborová M.1, Kolárik M.1, Indra R.1, Adam V.2, Heger Z.2, Kopečková K 3, Eckschlager T.3, Schmeiser H.H.4, Arlt V.M.5

1Department of biochemistry, Charles University, Albertov 6, 128 43 Prague 2; 2Department of Chemistry and Biochemistry, Mendel University in Brno, Zemedelska 1, 61300 Brno; 3Department of Pediatric Hematology and Oncology, and Department of Oncology, 2nd Medical Faculty, Charles University and University Hospital Motol, 150 06 Prague; 4Division of Radiopharmaceutical Chemistry, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, 69120 Heidelberg, German; 5Analytical and Environmental Sciences Division, MRC-PHE Centre for Environment and Health, King’s College London, Franklin-Wilkins Building, 150 Stamford Street, London, SE1 9NH, UK.

P-23 Bioactivation of the Carcinogen Aristolochic Acid I and II in SULT1B1-humanised mice

Moserová M.1, Reed L.2, Stiborová M1, Arlt V.M.2

1Department of biochemistry, Charles University, Albertov 6, 128 43 Prague 2, Czech Republic; 2Analytical and Environmental Sciences Division, MRC-PHE Centre for Environment and Health, King’s College London, Franklin-Wilkins Building, 150 Stamford Street, London, SE1 9NH, UK.

P-24 Identification of the enzymes metabolizing the inhibitor of tyrosine kinases lenvatinib

Vavrová K.1, Indra R.1, Pompach P.1, Heger Z.1, Adam V.2, Eckschlager T.3, Kopečková K.3, Stiborová M.1

1Department of Biochemistry, Faculty of Science, Charles University, Albertov 2030, 128 40 Prague 2, Czech Republic; 2Department of Chemistry and Biochemistry, Laboratory of Metallomics and Nanotechnology, Mendel University in Brno, Zemedelska 1, 61300 Brno, Czech Republic; 3Department of Pediatric Hematology and Oncology, 2nd Medical Faculty, Charles University and University Hospital Motol, 150 06 Prague, Czech Republic

P-25 INVOLVEMENT OF UGT ENZYMES IN FLAVONOLIGNAN METABOLISM

Vrba J.1, Lněničková K.1, Kosina P.1, Papoušková B.2, Ulrichová J.1

1Department of Medical Chemistry and Biochemistry, Faculty of Medicine and Dentistry, Palacký University, Olomouc, Czech Republic; 2Regional Centre of Advanced Technologies and Materials, Department of Analytical Chemistry, Faculty of Science, Palacký University, Olomouc, Czech Republic

P-26 Difference in cytochrome P450 expression and activities in liver microsomes after application of metronidazole. Comparison of control and germ-free mice

Zemanova N.1, Anzenbacher P.2, Zapletalova I.2, Lnenickova K.1, Vavreckova M.1, Hermanova P.3, Hudcovic T.3, Kozakova H.3, Anzenbacherova E.1

1Department of Medical Chemistry and Biochemistry and 2Departmenty of Pharmacology, Faculty of Medicine and Dentistry, Palacky University, Olomouc, Czech Republic, 3 Institute of Microbiology ASCR, Novy Hradek, Czech Republic

 

Methods in Toxicology

P-27 OPTIMIZATION OF THE LYMPHOCYTE PROLIFERATION ASSAY IN RAINBOW TROUT (ONCORHYNCHUS MYKISS)

Minarova H.1,2, Palikova M.1, Mares J.3, Syrova E.1,2, Blahova J.4, Faldyna M.2, Ondrackova P.2

1University of Veterinary and Pharmaceutical Sciences Brno, Faculty of Veterinary Hygiene and Ecology, Department of Ecology and Diseases of Game, Fish and Bees, Brno, Czech Republic; 2Veterinary Research Institute, Department of Immunology, Brno, Czech Republic; 3Mendel University in Brno, Faculty of AgriSciences, Department of Zoology, Fisheries, Hydrobiology and Apiculture, Brno, Czech Republic; 4University of Veterinary and Pharmaceutical Sciences Brno, Faculty of Veterinary Hygiene and Ecology, Department of Animal Protection, Welfare and Behaviour, Brno, Czech Republic

P-28 The use of alternative methods to animal testing in frame of the REACH regulation

Zatkova M.1, Balejikova J.1

1Ministry of Economy of the Slovak Republic, Centre for Chemical Substances and Preparations, Bratislava, Slovakia

 

Nanotoxicology

P-29 INVESTIGATION OF INTERACTIONS OF VANDETANIB WITH APOFERRITIN

Jáklová K.1, Indra R.1, Dostálová S.2, Heger Z.2, Adam V.2, Stiborová M.1

1Department of Biochemistry, Faculty of Science, Charles University, Prague, Czech Republic; 2Department of Chemistry and Biochemistry, Laboratory of Metallomics and Nanotechnology, Mendel University in Brno, Brno, Czech Republic

P-30 ALTERATION OF VIABILITY AND FUNCTIONAL STATE OF GONADAL CELLS BY METAL NANOPARTICLES

Scsuková S., Bujňáková Mlynarčíková A.

Institute of Experimental Endocrinology, Biomedical Research Center, Slovak Academy of Sciences, Bratislava, Slovakia

P-31 Construction of nanoparticles bearing lenvatinib: theoretical and practical approaches

Takácsová P.1, Indra R.1, Heger Z.2, Adam V.2, Barvík I.3, Stiborová M.1

1Department of Biochemistry, Faculty of Science, Charles University, Prague, Czech Republic; 2Department of Chemistry and Biochemistry, Laboratory of Metallomics and Nanotechnology, Mendel University in Brno, Brno, Czech Republic; 3Division of Biomolecular Physics, Institute of Physics, Faculty of Mathematics and Physics, Charles University, Ke Karlovu 5, 121 16 Prague 2, Czech Republic

   

 

Pharmacotoxicology

P-32 Synthesis of phenylethanoid glycopyranosides and their structure vs. activity assessment in cell-free tests and on human cells cutured in vitro

Horváthová E.1, Mastihubová M.2, Karnišová Potocká E.2, Kis P.2, Gálová E.3, Ševčovičová A.3, Klapáková M.3, Hunáková Ľ. 1, Mastihuba V.2

1 Cancer Research Institute BMC, University Science Park for Biomedicine, Slovak Academy of Sciences, Bratislava, Slovakia; 2 Institute of Chemistry, Slovak Academy of Sciences, Bratislava, Slovakia; 3 Department of Genetics, Faculty of Natural Sciences, Comenius University, Bratislava, Slovakia

P-33 Effect of venlafaxin treatment on metabolic risk factors and synaptic plasticity in hippocampus of rats with metabolic syndrome

Micháliková D.1,2, Sasváriová M.3, Švík K.1, Slovák L.1, Tyukos Kaprinay B.1, Sotníková R.1, Stankovičová T.3, Gáspárová Z.1

1Slovak Academy of Sciences, Centre of Experimental Medicine, Institute of Experimental Pharmacology and Toxicology, Bratislava, Slovak Republic; 2Comenius University in Bratislava, Jessenius Faculty of Medicine in Martin, Martin, Slovak Republic; 3Comenius University in Bratislava, Pharmaceutical Faculty, Bratislava, Slovak Republic

P-34 The effect of microbiome on pharmacokinetics of drugs. Example of metronidazole.

Anzenbacherova E. 1, Zemanova N.1,  Zapletalova I.2, Lnenickova K.1, Vavreckova M.1, Hermanova P.3, Hudcovic T.3, Kozakova H.3, Anzenbacher P.2

1Department of Medical Chemistry and Biochemistry and 2Departmenty of Pharmacology, Faculty of Medicine and Dentistry, Palacky University, Olomouc, Czech Republic, 3 Institute of Microbiology ASCR, Novy Hradek, Czech Republic

P-35 EVALUATION OF THE REPRODUCTIVE TOXICITY OF TOPICAL MINOXIDIL IN LABORATORY FEMALE RATS

Chemodurova N.1, Kuzminov B.1, Turkina V.1, Sklyarova H.2, Кuzminov Y.3

1Сentral research laboratory and laboratory of industrial toxicology; 2Faculty of Postgraduate Education; 3Department of Pediatrics, Danylo Halytsky Lviv National Medical University, Lviv, Ukraine.

P-36 Effect of repeated administration of haloperidol and aripiprazol on behavioural outcomes in chronic mild stress model in rats

Koprdova R.1, Osacka J.2, Kiss A.2, Mach M.1

1Institute of Experimental Pharmacology and Toxicology, Centre of Experimental Medicine, Slovak Academy of Sciences, Dubravska cesta 9, 841 04, Bratislava, Slovakia; 2Institute of Experimental Endocrinology, Biomedical Research Center, Slovak Academy of Sciences, Dubravska Cesta 9, 84104, Bratislava, Slovakia

P-37 Anti-inflammatory activity of resveratrol and its prenylated derivative on paw edema model in mice

Kuzmínová G.1, Šmejkal K.2, Klusáková J.3, Kružicová A.1, Horská K.1, Chalupová M.1, Račanská E.4, Bobál P.5, Pížová, H.5, Suchý P.1

1Department of Human Pharmacology and Toxicology, University of Veterinary and Pharmaceutical Sciences Brno, Brno, Czech Republic; 2Department of Natural Drugs, University of Veterinary and Pharmaceutical Sciences Brno, Brno, Czech Republic; 3MDgK spol. s r.o., Brno, Czech Republic; 4Department of Pharmacology and Toxicology, Comenius University in Bratislava, Bratislava, Slovak Republic; 5Department of Chemical Drugs, University of Veterinary and Pharmaceutical Sciences Brno, Brno, Czech Republic

P-38 Effect of venlafaxine on the function of isolated rat heart modified by high-fat-fructose diet

Salvaras, L.1, Knezl, V.2, Sasváriová, M.1, Micháliková, D.2, Tykos Kaprinay, B.2, Gáspárová, Z.2, Stankovičová, T 1.

1Department of Pharmacology and Toxicology, Faculty of Pharmacy, Comenius University in Bratislava, Bratislava, Slovak Republic; 2Institute of Experimental Pharmacology and Toxicology, Centre of Experimental Medicine, Slovak Academy of Sciences, Bratislava, Slovak Republic.

P-39 GENERAL TOXICITY ASSESSMENT OF THE NOVEL ALDOSE REDUCTASE INHIBITOR CEMTIRESTAT

Soltesova Prnova M.1,  Balekova J.1,  Kovacikova L.1, Lomenova J. 1, Michalikova S. 1  Rackova L.1, Karasu C.2 ,  Stefek, M.1

1Department of Biochemical Pharmacology, Institute of Experimental Pharmacology and Toxicology, CEM, Slovak Academy of Sciences, Dubravska cesta 9, 84104 Bratislava, Slovakia; 2Department of Medical Pharmacology, Faculty of Medicine, Gazi University, 06510, Beşevler, Ankara, Turkey

P-40 COMPARATIVE EFFECTS OF CEMTIRESTAT, STOBADINE AND EPALRESTAT ON GLUTATHIONE-S-TRANSFERASE AND CATALASE ACTIVITIES IN THE LIVER AND LUNG OF DIABETIC RATS GIVEN HIGH FRUCTOSE DIET AND STREPTOZOTOCIN

Afandiyeva N 1, Elmazoglu Z.2, Bek Aydin Z.2,  Ceylan Asli F.3, Stefek M.4, Kavutcu M.1  Karasu C.2

1Gazi University, Faculty of Medicine, Department of Medical Biochemistry, Ankara, Turkey; 2Gazi University, Faculty of Medicine, Department of Medical Pharmacology, Ankara, Turkey;  3Ankara Yildirim Beyazit University, Faculty of Medicine, Department of Medical Pharmacology, Ankara, Turkey; 4Slovak Academy of Sciences, CEM, Institute of Experimental Pharmacology and Toxicology, Bratislava, Slovakia

P-41 Pseurotins as potential cytostatics in human lymphomas

Vasicek O.1,2, Mosejova E.1, Bosnjakovic R.1,3, Kubala L.1,2

1Institute of Biophysics, Academy of Sciences of the Czech Republic, v. v. i., Brno, Czech Republic; 2International Clinical Research Center – Centre of Biomolecular and Cellular Engineering, St. Anne‘s University Hospital, Brno, Czech Republic; 3Department of Biology, Josip Juraj Strossmayer University of Osijek, Osijek, 31000, Croatia

P-42 Effect of Coenzyme Q10 and Different Varieties of Cornelian Cherry on Nitric Oxide Generation in the Heart and Aorta of Obese Zucker Rats

Dayar E., Cebova M., Kosutova M., Pechanova O.

Centre of Experimental Medicine, Slovak Academy of Sciences, Bratislava, Slovak Republic

 

Toxicology In Vitro

P-43 Action of bisphenol analogs on porcine granulosa cells

Bujňáková Mlynarčíková A., Scsuková S.

Institute of Experimental Endocrinology, Biomedical Research Center SAS, Bratislava, Slovakia

P-44 Bat liver cells: in vitro cytotoxicity of insecticides

Němcová M.1, Kováčová V.1, Zukal J.2, Pikula J.1

1Ústav ekologie a chorob zvěře, ryb a včel, Veterinární a farmaceutická univerzita Brno; 2Ústav biologie obratlovců Akademie věd ČR, v. v. i., Brno

P-45 INTERACTION OF NOVEL CDK INHIBITORS WITH HUMAN LIVER CYTOCHROMES P450

Špičáková A.1, Kraus P.3, Strnad M.3, Anzenbacher P.1,2

1Department of Pharmacology, Faculty of Medicine, Palacký University, Czech Republic; 2Institute of Molecular and Translational Medicine, Faculty of Medicine, Palacký University, Czech Republic; 3Laboratory of Growth Regulators, Faculty of Science, Palacký University, Czech Republic